Clinical therapeutic success with tumour patients, achieved in the department of oral and maxillofacial surgery at Erlangen University in 1989 and 1990, gave reason to a multiannual research project.

New therapeutic models and strategies – having led to these effective results – didn’t primary focus the destruction of tumour cells. The possibility of making an impact on the cell via the extracellular matrix had gained more and more significance.

Many questions came up:

• Which functional regulatory processes resulting from fields as well as cellular and molecular rhythms form the basis of the cell structures or extracellular matrix?
• Which methods were available to observe living cells?
• What importance had the “cell territories” for the differentiation of cells already described by R. Virchow in 1852?
• ....and many more....

The regulative effect of the extracellular matrix had to be submitted to a careful examination.

The therapy can be considered as a practical consequence of the results of the project “Clinical Fundamental Research” (1991 – 1998) at Erlangen University.